MolNFT v1 · #2391 · protein

Apo-mannose-binding protein-C

1BV4 · Protein (mannose-binding protein-C): “Apo-mannose-binding protein-C”. X-ray diffraction, 2 pockets (best druggability 0.71). MolNFT v1 #2391 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1BV4
Type: protein
Length: 412 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (mannose-binding protein-C)
UniProt: P08661
Pockets: 2 · best druggability 0.71

Structure

x-ray diffraction · 4 distinct chains · 19% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (mannose-binding protein-C)	protein	112	18% helix, 36% strand	P08661
B	Protein (mannose-binding protein-C)	protein	110	18% helix, 31% strand	P08661
C	Protein (mannose-binding protein-C)	protein	81	25% helix, 27% strand	P08661
D	Protein (mannose-binding protein-C)	protein	109	18% helix, 31% strand	P08661

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	921	0.71	0.76	71	empty
2	58	0.28	0.73	12	empty

Interfaces

4 interfaces between chains.

C–D · 710 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 698 Å² buried · 11 hydrogen bonds · protein-protein
B–D · 362 Å² buried · 9 hydrogen bonds · protein-protein
B–C · 30 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

1BV4 · Apo-mannose-binding protein-C · the same entry in another collection · chain D against D, TM-score 1.00
P08661 · AlphaFold monomer V2.0 prediction for mannose-binding protein C (P08661) · a predicted model of the same protein · chain C against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08661
Elsewhere: RCSB PDB 1BV4 · PDBe 1BV4 · UniProt P08661

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