MolNFT v1 · #23905 · protein
Crystal structure of DOK1 ptb domain complex
1UEF · Docking protein 1: “Crystal structure of DOK1 ptb domain complex”. X-ray diffraction, 1 pocket (best druggability 0.38). MolNFT v1 #23905 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1UEF
- Type
- protein
- Length
- 226 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Docking protein 1; 13-mer peptide from proto-oncogene tyrosine- protein kinase receptor…
- EC
- 2.7.1.112
- UniProt
- P97465, P35546
- Pockets
- 1 · best druggability 0.38
Structure
x-ray diffraction · 4 distinct chains · 20% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Docking protein 1 | protein | 105 | 23% helix, 46% strand | P97465 |
| B | Docking protein 1 | protein | 103 | 20% helix, 47% strand | P97465 |
| C | 13-mer peptide from proto-oncogene tyrosine- protein kinase receptor ret (EC 2.7.1.112) | protein | 10 | 0% helix, 30% strand | P35546 |
| D | 13-mer peptide from proto-oncogene tyrosine- protein kinase receptor ret (EC 2.7.1.112) | protein | 8 | 0% helix, 38% strand | P35546 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.38 | 0.75 | 19 | empty |
Interfaces
4 interfaces between chains.
- A–C · 674 Ų buried · 16 hydrogen bonds · protein-protein
- B–D · 662 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 581 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 16 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 1UEF · Crystal Structure of Dok1 PTB Domain Complex · the same entry in another collection · chain D against D, TM-score 1.00
- P97465 · AlphaFold monomer V2.0 prediction for docking protein 1 (P97465) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P35546 · AlphaFold monomer V2.0 prediction for proto-oncogene tyrosine-protein kinase receptor ret… · a predicted model of the same protein · chain D against A, TM-score 0.52
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P97465
- Every structure of UniProt P35546
- Elsewhere: RCSB PDB 1UEF · PDBe 1UEF · UniProt P97465 · UniProt P35546
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