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MolNFT v1 · #23868 · protein

Structure of udp-galactose-4-epimerase complexed with udp-4-deoxy-4- fluoro-alpha-D-galactose

1UDA: “Structure of udp-galactose-4-epimerase complexed with udp-4-deoxy-4- fluoro-alpha-D-galactose”. X-ray diffraction, 3 ligands (NAD, UFG, NA), 2 pockets (best druggability 0.83). MolNFT v1 #23868 on GenesisL1: 3D structure, binding…

PDB
1UDA
Type
protein
Length
338 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Udp-galactose-4-epimerase
EC
5.1.3.2
UniProt
P09147
Ligands
NAD, UFG, NA
Pockets
2 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AUdp-galactose-4-epimerase (EC 5.1.3.2)protein33841% helix, 18% strandP09147

Ligands and binding sites

  • NAD · Nicotinamide-adenine-dinucleotide · ligand · chains A
  • UFG · Uridine-5'-diphosphate-4-deoxy-4-fluoro-alpha-D-galactose · ligand · chains A
  • NA · Sodium ion · metal · 3 copies · chains A
  • PGE · Triethylene glycol · additive · chains A
  • EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
18580.830.8584NA, NAD, UFG, EDO
2560.540.8920empty

Compared structures

  • 1UDA · Structure of udp-galactose-4-epimerase complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
  • P09147 · AlphaFold monomer V2.0 prediction for udp-glucose 4-epimerase (P09147) · a predicted model of the same protein · chain A against A, TM-score 0.98

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