MolNFT v1 · #23821 · protein

Structure of farnesyl pyrophosphate synthetase

1UBV · Farnesyl diphosphate synthase: “Structure of farnesyl pyrophosphate synthetase”. X-ray diffraction, 2 pockets (best druggability 0.78). MolNFT v1 #23821 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1UBV
Type: protein
Length: 348 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Farnesyl diphosphate synthase
EC: 2.5.1.1
UniProt: P08836
Pockets: 2 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Farnesyl diphosphate synthase (EC 2.5.1.1)	protein	348	70% helix, 1% strand	P08836

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	983	0.78	0.80	71	empty
2	133	0.53	0.81	19	empty

Compared structures

1UBV · Structure of farnesyl pyrophosphate synthetase · the same entry in another collection · chain A against A, TM-score 1.00
P08836 · AlphaFold monomer V2.0 prediction for farnesyl pyrophosphate synthase (P08836) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08836
Elsewhere: RCSB PDB 1UBV · PDBe 1UBV · UniProt P08836

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