MolNFT v1 · #23797 · protein
Crystal structure of antibody 19G2 with sera ligand
1UB6 · Antibody 19G2, alpha chain: “Crystal structure of antibody 19G2 with sera ligand”. X-ray diffraction, 8 pockets (best druggability 0.71). MolNFT v1 #23797 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1UB6
- Type
- protein
- Length
- 842 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody 19G2, alpha chain; Antibody 19G2, beta chain
- UniProt
- P18527
- Pockets
- 8 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H, A | Antibody 19G2, alpha chain | protein | 208 | 4% helix, 50% strand | P18527 |
| L, B | Antibody 19G2, beta chain | protein | 213 | 6% helix, 48% strand | — |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 125 | 0.71 | 0.91 | 24 | empty |
| 2 | 114 | 0.70 | 0.92 | 25 | empty |
| 3 | 593 | 0.63 | 0.75 | 59 | empty |
| 4 | 433 | 0.57 | 0.74 | 54 | empty |
| 5 | 64 | 0.48 | 0.84 | 22 | empty |
Interfaces
2 interfaces between chains.
- H–L · 1807 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 1744 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18527
- Elsewhere: RCSB PDB 1UB6 · PDBe 1UB6 · UniProt P18527
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