MolNFT v1 · #23779 · protein
Crystal structure of TRNA(M1G37)METHYLTRANSFERASE: insight into tRNA recognition
1UAM · TRNA (guanine-N(1)-)-methyltransferase: “Crystal structure of TRNA(M1G37)METHYLTRANSFERASE: insight into tRNA recognition”. X-ray diffraction, 2 ligands (SAH, PO4), 2 pockets (best druggability 0.56). MolNFT v1 #23779 on GenesisL1…
- PDB
- 1UAM
- Type
- protein
- Length
- 250 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA (guanine-N(1)-)-methyltransferase
- EC
- 2.1.1.31
- UniProt
- P43912
- Ligands
- SAH, PO4
- Pockets
- 2 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA (guanine-N(1)-)-methyltransferase (EC 2.1.1.31) | protein | 250 | 42% helix, 17% strand | P43912 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 114 | 0.56 | 0.84 | 25 | SAH |
| 2 | 51 | 0.32 | 0.77 | 12 | empty |
Compared structures
- 1UAM · Crystal structure of tRNA(m1G37)methyltransferase: Insight into tRNA recognition · the same entry in another collection · chain A against A, TM-score 1.00
- P43912 · AlphaFold monomer V2.0 prediction for tRNA (guanine-N(1)-)-methyltransferase (P43912) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43912
- Elsewhere: RCSB PDB 1UAM · PDBe 1UAM · UniProt P43912
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