MolNFT v1 · #23675 · protein
Structure of a hexameric N-terminal domain from murine leukemia virus capsid
1U7K · Gag polyprotein: “Structure of a hexameric N-terminal domain from murine leukemia virus capsid”. X-ray diffraction, 11 pockets (best druggability 0.69). MolNFT v1 #23675 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1U7K
- Type
- protein
- Length
- 786 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gag polyprotein
- UniProt
- P03336
- Pockets
- 11 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 58% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Gag polyprotein | protein | 131 | 58% helix, 6% strand | P03336 |
Pockets
11 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 589 | 0.69 | 0.78 | 56 | empty |
| 2 | 508 | 0.69 | 0.79 | 58 | empty |
| 3 | 927 | 0.67 | 0.73 | 86 | empty |
| 4 | 316 | 0.60 | 0.78 | 29 | empty |
| 5 | 255 | 0.59 | 0.79 | 39 | empty |
Interfaces
6 interfaces between chains.
- A–B · 676 Ų buried · 8 hydrogen bonds · protein-protein
- E–F · 658 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 649 Ų buried · 9 hydrogen bonds · protein-protein
- D–E · 632 Ų buried · 9 hydrogen bonds · protein-protein
- A–F · 631 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 1U7K · Structure of a hexameric N-terminal domain from murine leukemia virus capsid · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03336
- Elsewhere: RCSB PDB 1U7K · PDBe 1U7K · UniProt P03336
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.