MolNFT v1 · #23665 · protein + DNA
Structure of the bipartite DNA-binding domain of TC3 transposase bound to transposon DNA
1U78 · 26-mer: “Structure of the bipartite DNA-binding domain of TC3 transposase bound to transposon DNA”. X-ray diffraction, 3 pockets (best druggability 0.48). MolNFT v1 #23665 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1U78
- Type
- protein + DNA
- Length
- 155 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 26-mer; Transposable element TC3 transposase
- UniProt
- P34257
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · 3 distinct chains · 60% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | 26-mer | dna | 26 | — | — |
| C | 26-mer | dna | 26 | — | — |
| A | Transposable element TC3 transposase | protein | 103 | 60% helix, 0% strand | P34257 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 139 | 0.48 | 0.79 | 21 | empty |
| 2 | 92 | 0.34 | 0.74 | 15 | empty |
| 3 | 57 | 0.24 | 0.72 | 16 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1160 Ų buried · 127 hydrogen bonds · nucleic-nucleic
- C–A · 1134 Ų buried · 29 hydrogen bonds · protein-nucleic
- B–A · 1044 Ų buried · 29 hydrogen bonds · protein-nucleic
Compared structures
- 1U78 · Structure of the bipartite DNA-binding domain of Tc3 transposase bound to transposon DNA · the same entry in another collection · chain B against B, TM-score 1.00
- P34257 · AlphaFold monomer V2.0 prediction for transposable element TC3 transposase (P34257) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P34257
- Elsewhere: RCSB PDB 1U78 · PDBe 1U78 · UniProt P34257
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