MolNFT v1 · #23506 · protein
Triglycine variant of the arno pleckstrin homology domain in complex with INS(1,4,5)P3
1U29 · Cytohesin 2: “Triglycine variant of the arno pleckstrin homology domain in complex with INS(1,4,5)P3”. X-ray diffraction, 1 ligand (I3P), 1 pocket (best druggability 0.33). MolNFT v1 #23506 on GenesisL1: 3D structure, binding sites…
- PDB
- 1U29
- Type
- protein
- Length
- 119 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytohesin 2
- UniProt
- P63034
- Ligands
- I3P
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 1 distinct chain · 13% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytohesin 2 | protein | 119 | 13% helix, 39% strand | P63034 |
Ligands and binding sites
- I3P · D-myo-inositol-1,4,5-triphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.33 | 0.77 | 24 | I3P |
Compared structures
- 1U29 · Triglycine variant of the ARNO Pleckstrin Homology Domain in complex with Ins(1,4,5)P3 · the same entry in another collection · chain A against A, TM-score 1.00
- P63034 · AlphaFold monomer V2.0 prediction for cytohesin-2 (P63034) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63034
- Elsewhere: RCSB PDB 1U29 · PDBe 1U29 · UniProt P63034
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