MolNFT v1 · #23371 · protein
Structural analysis of a series of mutants of tyrosyl-tRNA synthetase: enhancement of catalysis by hydrophobic interactions
1TYC: “Structural analysis of a series of mutants of tyrosyl-tRNA synthetase: enhancement of catalysis by…”. X-ray diffraction, 2 pockets (best druggability 0.69). MolNFT v1 #23371 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1TYC
- Type
- protein
- Length
- 317 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosyl-tRNA synthetase
- EC
- 6.1.1.1
- UniProt
- P00952
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 54% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosyl-tRNA synthetase (EC 6.1.1.1) | protein | 317 | 54% helix, 10% strand | P00952 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 427 | 0.69 | 0.81 | 45 | empty |
| 2 | 142 | 0.42 | 0.74 | 23 | empty |
Compared structures
- 1TYC · Structural analysis of a series of mutants of tyrosyl-tRNA synthetase: enhancement of… · the same entry in another collection · chain A against A, TM-score 1.00
- P00952 · AlphaFold monomer V2.0 prediction for tyrosine--tRNA ligase (P00952) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00952
- Elsewhere: RCSB PDB 1TYC · PDBe 1TYC · UniProt P00952
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