MolNFT v1 · #23300 · protein

Crystal structure of 3-hydroxy-3-methylglutaryl-coenzyme a synthase from staphylococcus aureus

1TVZ · 3-hydroxy-3-methylglutaryl-CoA synthase: “Crystal structure of 3-hydroxy-3-methylglutaryl-coenzyme a synthase from staphylococcus aureus”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.62). MolNFT v1 #23300 on…

PDB: 1TVZ
Type: protein
Length: 387 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3-hydroxy-3-methylglutaryl-CoA synthase
EC: 4.1.3.5
Ligands: SO4
Pockets: 4 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3-hydroxy-3-methylglutaryl-CoA synthase (EC 4.1.3.5)	protein	387	40% helix, 25% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	139	0.62	0.85	21	empty
2	157	0.59	0.83	21	empty
3	154	0.43	0.75	28	empty
4	104	0.39	0.76	19	empty

Modifications

Observed in the structure: 1 modified (oxidation).

Compared structures

1TVZ · Crystal structure of 3-hydroxy-3-methylglutaryl-coenzyme A synthase from Staphylococcus… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1TVZ · PDBe 1TVZ

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.