MolNFT v1 · #23272 · protein

Structure of the S-adenosylmethionine dependent enzyme moaa

1TV7 · Molybdenum cofactor biosynthesis protein a: “Structure of the S-adenosylmethionine dependent enzyme moaa”. X-ray diffraction, 2 ligands (SF4, SO4), 5 pockets (best druggability 0.82). MolNFT v1 #23272 on GenesisL1: 3D structure…

PDB: 1TV7
Type: protein
Length: 653 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Molybdenum cofactor biosynthesis protein a
UniProt: Q99S04
Ligands: SF4, SO4
Pockets: 5 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Molybdenum cofactor biosynthesis protein a	protein	327	36% helix, 18% strand	Q99S04
B	Molybdenum cofactor biosynthesis protein a	protein	326	36% helix, 19% strand	Q99S04

Ligands and binding sites

SF4 · Iron/sulfur cluster · ligand · 4 copies · chains A, B
SO4 · Sulfate ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1099	0.82	0.83	98	SO4, SF4
2	572	0.82	0.87	76	empty
3	1153	0.81	0.82	86	SO4, SF4
4	80	0.31	0.73	19	empty
5	73	0.30	0.73	19	empty

Interfaces

1 interface between chains.

A–B · 1491 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

1TV7 · Structure of the S-adenosylmethionine dependent Enzyme MoaA · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99S04
Elsewhere: RCSB PDB 1TV7 · PDBe 1TV7 · UniProt Q99S04

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