MolNFT v1 · #23245 · protein

The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2

1TUE · Replication protein E1: “The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2”. X-ray diffraction, 20 pockets (best druggability 0.79). MolNFT v1 #23245 on GenesisL1: 3D structure, binding…

PDB: 1TUE
Type: protein
Length: 2,337 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Replication protein E1; Regulatory protein E2
UniProt: P06789, Q80B71
Pockets: 20 · best druggability 0.79

Structure

x-ray diffraction · 11 distinct chains · 41% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Replication protein E1	protein	201	43% helix, 15% strand	P06789
B	Regulatory protein E2	protein	194	40% helix, 27% strand	Q80B71
D	Replication protein E1	protein	202	43% helix, 15% strand	P06789
E	Regulatory protein E2	protein	196	39% helix, 29% strand	Q80B71
F	Replication protein E1	protein	188	40% helix, 12% strand	P06789
G	Regulatory protein E2	protein	196	40% helix, 26% strand	Q80B71
H	Replication protein E1	protein	191	46% helix, 13% strand	P06789
J, Q	Regulatory protein E2	protein	194	40% helix, 28% strand	Q80B71
K	Replication protein E1	protein	192	45% helix, 13% strand	P06789
L	Regulatory protein E2	protein	193	38% helix, 28% strand	Q80B71
M	Replication protein E1	protein	196	42% helix, 14% strand	P06789

Pockets

20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	770	0.79	0.83	104	empty
2	876	0.72	0.77	78	empty
3	271	0.66	0.82	29	empty
4	564	0.61	0.74	55	empty
5	55	0.61	0.92	20	empty

Interfaces

16 interfaces between chains.

F–G · 1112 Å² buried · 14 hydrogen bonds · protein-protein
A–H · 1108 Å² buried · 5 hydrogen bonds · protein-protein
K–L · 1091 Å² buried · 16 hydrogen bonds · protein-protein
H–J · 1077 Å² buried · 14 hydrogen bonds · protein-protein
M–Q · 1035 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

1TUE · The X-ray Structure of the Papillomavirus Helicase in Complex with its Molecular… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06789
Every structure of UniProt Q80B71
Elsewhere: RCSB PDB 1TUE · PDBe 1TUE · UniProt P06789 · UniProt Q80B71

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.