MolNFT v1 · #23225 · protein + DNA
Crystal structure of csl bound to DNA
1TTU · 5'- D(*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3': “Crystal structure of csl bound to DNA”. X-ray diffraction, 7 pockets (best druggability 0.77). MolNFT v1 #23225 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1TTU
- Type
- protein + DNA
- Length
- 465 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'- D(*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'; 5'…
- UniProt
- Q9TYY1
- Pockets
- 7 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 11% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | 5'- D(*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3' | dna | 15 | — | — |
| C | 5'- D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*T)-3' | dna | 15 | — | — |
| A | Lin-12 and glp-1 transcriptional regulator | protein | 435 | 11% helix, 41% strand | Q9TYY1 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 9 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 695 | 0.77 | 0.82 | 77 | EDO |
| 2 | 150 | 0.47 | 0.77 | 23 | EDO |
| 3 | 154 | 0.46 | 0.76 | 24 | empty |
| 4 | 65 | 0.36 | 0.78 | 16 | empty |
| 5 | 53 | 0.35 | 0.79 | 16 | EDO |
Interfaces
3 interfaces between chains.
- C–A · 636 Ų buried · 14 hydrogen bonds · protein-nucleic
- B–C · 593 Ų buried · 63 hydrogen bonds · nucleic-nucleic
- B–A · 561 Ų buried · 12 hydrogen bonds · protein-nucleic
Compared structures
- 1TTU · Crystal Structure of CSL bound to DNA · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9TYY1
- Elsewhere: RCSB PDB 1TTU · PDBe 1TTU · UniProt Q9TYY1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.