MolNFT v1 · #23205 · protein
Structure of the bifunctional and golgi associated formiminotransferase cyclodeaminase octamer
1TT9 · Formimidoyltransferase-cyclodeaminase…: “Structure of the bifunctional and golgi associated formiminotransferase cyclodeaminase octamer”. X-ray diffraction, 12 pockets (best druggability 0.68). MolNFT v1 #23205 on GenesisL1: 3D…
- PDB
- 1TT9
- Type
- protein
- Length
- 2,160 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Formimidoyltransferase-cyclodeaminase (formiminotransferase- cyclodeaminase) (ftcd) (58…
- EC
- 2.1.2.5, 4.3.1.4
- UniProt
- O88618
- Pockets
- 12 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Formimidoyltransferase-cyclodeaminase (formiminotransferase- cyclodeaminase) (ftcd) (58 kda microtubule- binding protein) (EC 2.1.2.5, 4.3.1.4) | protein | 540 | 0% helix, 0% strand | O88618 |
Pockets
12 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 683 | 0.68 | 0.74 | 108 | empty |
| 2 | 460 | 0.61 | 0.73 | 85 | empty |
| 3 | 196 | 0.46 | 0.72 | 49 | empty |
| 4 | 133 | 0.41 | 0.73 | 41 | empty |
| 5 | 117 | 0.40 | 0.73 | 28 | empty |
Interfaces
2 interfaces between chains.
- A–B · 406 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 383 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 modified (engineered).
Compared structures
- 1TT9 · Structure of the bifunctional and Golgi associated formiminotransferase cyclodeaminase… · the same entry in another collection · chain D against D, TM-score 1.00
- O88618 · AlphaFold monomer V2.0 prediction for formimidoyltransferase- cyclodeaminase (O88618) · a predicted model of the same protein · chain B against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O88618
- Elsewhere: RCSB PDB 1TT9 · PDBe 1TT9 · UniProt O88618
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