MolNFT v1 · #23090 · protein

The three-dimensional structure of tyrosine phenol-lyase

1TPL: “The three-dimensional structure of tyrosine phenol-lyase”. X-ray diffraction, 1 ligand (SO4), 12 pockets (best druggability 0.64). MolNFT v1 #23090 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1TPL
Type: protein
Length: 852 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine phenol-lyase
EC: 4.1.99.2
UniProt: P31012
Ligands: SO4
Pockets: 12 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine phenol-lyase (EC 4.1.99.2)	protein	426	43% helix, 16% strand	P31012
B	Tyrosine phenol-lyase (EC 4.1.99.2)	protein	426	43% helix, 18% strand	P31012

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	404	0.64	0.78	57	empty
2	460	0.62	0.76	61	SO4
3	394	0.58	0.75	57	empty
4	178	0.52	0.78	28	empty
5	117	0.43	0.77	20	empty

Interfaces

1 interface between chains.

A–B · 1871 Å² buried · 32 hydrogen bonds · protein-protein

Compared structures

1TPL · The three-dimensional structure of tyrosine phenol-lyase · the same entry in another collection · chain A against A, TM-score 1.00
P31012 · AlphaFold monomer V2.0 prediction for tyrosine phenol-lyase (P31012) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31012
Elsewhere: RCSB PDB 1TPL · PDBe 1TPL · UniProt P31012

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.