MolNFT v1 · #22949 · protein + DNA
Human DNA topoisomerase I (70 kda) in complex with the indenoisoquinoline ai-III-52 and covalent complex with a 22 base pair DNA duplex
1TL8: “Human DNA topoisomerase I (70 kda) in complex with the indenoisoquinoline ai-III-52 and covalent complex with…”. X-ray diffraction. MolNFT v1 #22949 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1TL8
- Type
- protein + DNA
- Length
- 609 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P11387
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | — | dna | 10 | — | — |
| C | — | dna | 12 | — | — |
| D | — | dna | 22 | — | — |
| A | — | protein | 565 | — | P11387 |
Compared structures
- 1TL8 · Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and… · the same entry in another collection · chain B against B, TM-score 1.00
- P11387 · AlphaFold monomer V2.0 prediction for DNA topoisomerase 1 (P11387) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11387
- Elsewhere: RCSB PDB 1TL8 · PDBe 1TL8 · UniProt P11387
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