MolNFT v1 · #22934 · protein
Crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of candida albicans
1TKS: “Crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of candida albicans”. X-ray diffraction, 2 pockets (best druggability 0.53). MolNFT v1 #22934 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1TKS
- Type
- protein
- Length
- 392 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3,4-dihydroxy-2-butanone 4-phosphate synthase
- EC
- 5.4.99.-
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 3,4-dihydroxy-2-butanone 4-phosphate synthase (EC 5.4.99.-) | protein | 196 | 38% helix, 24% strand | — |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 208 | 0.53 | 0.78 | 28 | empty |
| 2 | 162 | 0.51 | 0.79 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 1213 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 1TKS · Crystal structure of 3,4-Dihydroxy-2-buta 4-phosphate Synthase of Candida albicans · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1TKS · PDBe 1TKS
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