MolNFT v1 · #22928 · protein

Yeast oxygen-dependent coproporphyrinogen oxidase

1TKL · Coproporphyrinogen III oxidase: “Yeast oxygen-dependent coproporphyrinogen oxidase”. X-ray diffraction, 6 pockets (best druggability 0.82). MolNFT v1 #22928 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1TKL
Type: protein
Length: 650 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Coproporphyrinogen III oxidase
EC: 1.3.3.3
UniProt: P11353
Pockets: 6 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Coproporphyrinogen III oxidase (EC 1.3.3.3)	protein	325	41% helix, 26% strand	P11353

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	811	0.82	0.85	67	empty
2	850	0.79	0.82	60	empty
3	198	0.47	0.75	29	empty
4	111	0.42	0.77	23	empty
5	83	0.35	0.75	18	empty

Interfaces

1 interface between chains.

A–B · 1411 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

1TKL · Yeast Oxygen-Dependent Coproporphyrinogen Oxidase · the same entry in another collection · chain A against A, TM-score 1.00
P11353 · AlphaFold monomer V2.0 prediction for oxygen-dependent coproporphyrinogen-III oxidase… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11353
Elsewhere: RCSB PDB 1TKL · PDBe 1TKL · UniProt P11353

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