MolNFT v1 · #22925 · protein

Autoinhibited serine kinase domain of the giant muscle protein titin

1TKI: “Autoinhibited serine kinase domain of the giant muscle protein titin”. X-ray diffraction, 8 pockets (best druggability 0.73). MolNFT v1 #22925 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1TKI
Type: protein
Length: 642 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Titin
UniProt: Q10466
Pockets: 8 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Titin	protein	321	38% helix, 20% strand	Q10466

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	358	0.73	0.85	35	empty
2	333	0.72	0.84	31	empty
3	176	0.48	0.76	22	empty
4	152	0.47	0.77	18	empty
5	89	0.41	0.78	20	empty

Compared structures

1TKI · Autoinhibited serine kinase domain of the giant muscle protein titin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q10466
Elsewhere: RCSB PDB 1TKI · PDBe 1TKI · UniProt Q10466

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.