MolNFT v1 · #22879 · protein
Crystal structure of the xenopus tropicalis SPRED1 evh-1 domain
1TJ6: “Crystal structure of the xenopus tropicalis SPRED1 evh-1 domain”. X-ray diffraction, 2 pockets (best druggability 0.53). MolNFT v1 #22879 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1TJ6
- Type
- protein
- Length
- 222 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SPRED1
- UniProt
- Q66JG9
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 18% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SPRED1 | protein | 115 | 17% helix, 47% strand | Q66JG9 |
| B | SPRED1 | protein | 107 | 20% helix, 50% strand | Q66JG9 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 185 | 0.53 | 0.79 | 24 | empty |
| 2 | 52 | 0.31 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 314 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1TJ6 · Crystal structure of the Xenopus tropicalis Spred1 EVH-1 domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q66JG9 · AlphaFold monomer V2.0 prediction for sprouty-related, EVH1 domain- containing protein 1… · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q66JG9
- Elsewhere: RCSB PDB 1TJ6 · PDBe 1TJ6 · UniProt Q66JG9
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