MolNFT v1 · #22851 · protein

Conformational lability of lipases observed in the absence of an oil- water interface: crystallographic studies of enzymes from the fungi humicola lanuginosa and rhizopus delemar

1TIC: “Conformational lability of lipases observed in the absence of an oil- water interface: crystallographic…”. X-ray diffraction, 3 pockets (best druggability 0.34). MolNFT v1 #22851 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1TIC
Type: protein
Length: 534 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipase
EC: 3.1.1.3
UniProt: P61872
Pockets: 3 · best druggability 0.34

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lipase (EC 3.1.1.3)	protein	265	0% helix, 0% strand	P61872
B	Lipase (EC 3.1.1.3)	protein	269	0% helix, 0% strand	P61872

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	81	0.34	0.73	27	empty
2	78	0.33	0.72	24	empty
3	57	0.28	0.72	17	empty

Interfaces

1 interface between chains.

A–B · 51 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1TIC · Conformational lability of lipases observed in the absence of an oil-water interface… · the same entry in another collection · chain A against A, TM-score 1.00
P61872 · AlphaFold monomer V2.0 prediction for lipase (P61872) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61872
Elsewhere: RCSB PDB 1TIC · PDBe 1TIC · UniProt P61872

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.