MolNFT v1 · #22849 · protein

An unusual buried polar cluster in a family of fungal lipases

1TIA: “An unusual buried polar cluster in a family of fungal lipases”. X-ray diffraction, 3 pockets (best druggability 0.46). MolNFT v1 #22849 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1TIA
Type: protein
Length: 271 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipase
EC: 3.1.1.3
UniProt: P61870
Pockets: 3 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lipase (EC 3.1.1.3)	protein	271	0% helix, 0% strand	P61870

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	173	0.46	0.73	41	empty
2	103	0.36	0.73	25	empty
3	89	0.33	0.73	20	empty

Compared structures

1TIA · An unusual buried polar cluster in a family of fungal lipases · the same entry in another collection · chain A against A, TM-score 1.00
P61870 · AlphaFold monomer V2.0 prediction for mono- and diacylglycerol lipase (P61870) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61870
Elsewhere: RCSB PDB 1TIA · PDBe 1TIA · UniProt P61870

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