MolNFT v1 · #22794 · protein + DNA

Tata binding protein (TBP)/DNA complex

1TGH · DNA (5'-D(*CP*GP*TP*AP*TP*AP*TP*AP*TP*AP*CP*G)- 3'): “Tata binding protein (TBP)/DNA complex”. X-ray diffraction, 1 pocket (best druggability 0.24). MolNFT v1 #22794 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1TGH
Type: protein + DNA
Length: 204 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (5'-D(*CP*GP*TP*AP*TP*AP*TP*AP*TP*AP*CP*G)- 3'); Protein (tata binding protein (tbp))
UniProt: P20226
Pockets: 1 · best druggability 0.24

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, C	DNA (5'-D(CPGPTPAPTPAPTPAPTPAPCPG)- 3')	dna	12	—	—
A	Protein (tata binding protein (tbp))	protein	180	26% helix, 33% strand	P20226

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.24	0.71	12	empty

Interfaces

3 interfaces between chains.

C–A · 902 Å² buried · 10 hydrogen bonds · protein-nucleic
B–A · 800 Å² buried · 5 hydrogen bonds · protein-nucleic
B–C · 554 Å² buried · 49 hydrogen bonds · nucleic-nucleic

Compared structures

1TGH · Tata binding protein (TBP)/DNA complex · the same entry in another collection · chain B against B, TM-score 1.00
P20226 · AlphaFold monomer V2.0 prediction for tata-box-binding protein (P20226) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P20226
Elsewhere: RCSB PDB 1TGH · PDBe 1TGH · UniProt P20226

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