MolNFT v1 · #22750 · protein

Crystal structure of seca in an open conformation from bacillus subtilis

1TF5 · Preprotein translocase seca subunit: “Crystal structure of seca in an open conformation from bacillus subtilis”. X-ray diffraction, 7 pockets (best druggability 0.73). MolNFT v1 #22750 on GenesisL1: 3D structure, binding sites and…

PDB: 1TF5
Type: protein
Length: 775 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Preprotein translocase seca subunit
UniProt: P28366
Pockets: 7 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Preprotein translocase seca subunit	protein	775	53% helix, 12% strand	P28366

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	476	0.73	0.83	74	empty
2	256	0.59	0.79	32	empty
3	183	0.54	0.79	24	empty
4	208	0.53	0.77	23	empty
5	174	0.48	0.76	39	empty

Compared structures

1TF5 · Crystal structure of SecA in an open conformation from Bacillus Subtilis · the same entry in another collection · chain A against A, TM-score 1.00
P28366 · AlphaFold monomer V2.0 prediction for protein translocase subunit seca (P28366) · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28366
Elsewhere: RCSB PDB 1TF5 · PDBe 1TF5 · UniProt P28366

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