MolNFT v1 · #22645 · protein
H141N mutant of rat liver arginase I
1TBL · Arginase 1: “H141N mutant of rat liver arginase I”. X-ray diffraction, 1 ligand (MN), 11 pockets (best druggability 0.81). MolNFT v1 #22645 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1TBL
- Type
- protein
- Length
- 942 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Arginase 1
- EC
- 3.5.3.1
- UniProt
- P07824
- Ligands
- MN
- Pockets
- 11 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Arginase 1 (EC 3.5.3.1) | protein | 314 | 38% helix, 16% strand | P07824 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 6 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 941 | 0.81 | 0.83 | 78 | empty |
| 2 | 261 | 0.57 | 0.78 | 31 | empty |
| 3 | 208 | 0.55 | 0.79 | 30 | empty |
| 4 | 213 | 0.55 | 0.78 | 30 | empty |
| 5 | 70 | 0.48 | 0.84 | 16 | empty |
Interfaces
3 interfaces between chains.
- B–C · 968 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 955 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 950 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07824
- Elsewhere: RCSB PDB 1TBL · PDBe 1TBL · UniProt P07824
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.