MolNFT v1 · #22642 · protein
H141D mutant of rat liver arginase I
1TBH · Arginase 1: “H141D mutant of rat liver arginase I”. X-ray diffraction, 1 ligand (MN), 10 pockets (best druggability 0.80). MolNFT v1 #22642 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1TBH
- Type
- protein
- Length
- 942 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Arginase 1
- EC
- 3.5.3.1
- UniProt
- P07824
- Ligands
- MN
- Pockets
- 10 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Arginase 1 (EC 3.5.3.1) | protein | 314 | 41% helix, 17% strand | P07824 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 6 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1174 | 0.80 | 0.82 | 98 | empty |
| 2 | 212 | 0.54 | 0.78 | 30 | empty |
| 3 | 138 | 0.53 | 0.81 | 23 | empty |
| 4 | 129 | 0.50 | 0.79 | 24 | empty |
| 5 | 130 | 0.49 | 0.80 | 22 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1004 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 1001 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 942 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07824
- Elsewhere: RCSB PDB 1TBH · PDBe 1TBH · UniProt P07824
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