MolNFT v1 · #22520 · protein

Crystal structure of the M564G mutant of murine crat

1T7N · Carnitine acetyltransferase: “Crystal structure of the M564G mutant of murine crat”. X-ray diffraction, 5 pockets (best druggability 0.78). MolNFT v1 #22520 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1T7N
Type: protein
Length: 599 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Carnitine acetyltransferase
UniProt: P47934
Pockets: 5 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Carnitine acetyltransferase	protein	599	46% helix, 16% strand	P47934

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	913	0.78	0.80	76	empty
2	189	0.54	0.79	27	empty
3	135	0.51	0.80	17	empty
4	82	0.48	0.82	20	empty
5	81	0.34	0.75	16	empty

Compared structures

1T7N · Crystal structure of the M564G mutant of murine CrAT · the same entry in another collection · chain A against A, TM-score 1.00
P47934 · AlphaFold monomer V2.0 prediction for carnitine O-acetyltransferase (P47934) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P47934
Elsewhere: RCSB PDB 1T7N · PDBe 1T7N · UniProt P47934

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