MolNFT v1 · #22420 · protein

Crystal structure of RNT1P dsrbd

1T4O · Ribonuclease III: “Crystal structure of RNT1P dsrbd”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #22420 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1T4O
Type: protein
Length: 169 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribonuclease III
EC: 3.1.26.3
UniProt: Q02555
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribonuclease III (EC 3.1.26.3)	protein	81	41% helix, 23% strand	Q02555
B	Ribonuclease III (EC 3.1.26.3)	protein	88	39% helix, 22% strand	Q02555

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	105	0.37	0.75	21	empty

Interfaces

1 interface between chains.

A–B · 415 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

1T4O · Crystal structure of rnt1p dsRBD · the same entry in another collection · chain A against A, TM-score 1.00
Q02555 · AlphaFold monomer V2.0 prediction for ribonuclease 3 (Q02555) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02555
Elsewhere: RCSB PDB 1T4O · PDBe 1T4O · UniProt Q02555

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