MolNFT v1 · #22336 · protein

The structure of pitp complexed to phosphatidylcholine

1T27 · Phosphatidylinositol transfer protein alpha isoform: “The structure of pitp complexed to phosphatidylcholine”. X-ray diffraction, 1 ligand (PCW), 1 pocket (best druggability 0.87). MolNFT v1 #22336 on GenesisL1: 3D structure…

PDB: 1T27
Type: protein
Length: 269 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphatidylinositol transfer protein alpha isoform
UniProt: P16446
Ligands: PCW
Pockets: 1 · best druggability 0.87

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphatidylinositol transfer protein alpha isoform	protein	269	33% helix, 27% strand	P16446

Ligands and binding sites

PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	955	0.87	0.88	87	PCW

Compared structures

1T27 · The structure of pitp complexed to phosphatidylcholine · the same entry in another collection · chain A against A, TM-score 1.00
P16446 · AlphaFold monomer V2.0 prediction for phosphatidylinositol transfer protein alpha isoform… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P16446
Elsewhere: RCSB PDB 1T27 · PDBe 1T27 · UniProt P16446

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