MolNFT v1 · #22231 · protein
The RNA polymerase II ctd in mRNA processing: beta-turn recognition and beta-spiral model
1SZ9 · PCF11 protein: “The RNA polymerase II ctd in mRNA processing: beta-turn recognition and beta-spiral model”. X-ray diffraction, 5 pockets (best druggability 0.75). MolNFT v1 #22231 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1SZ9
- Type
- protein
- Length
- 426 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PCF11 protein
- UniProt
- P39081
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | PCF11 protein | protein | 143 | 75% helix, 0% strand | P39081 |
| C | PCF11 protein | protein | 140 | 77% helix, 0% strand | P39081 |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 371 | 0.75 | 0.85 | 36 | empty |
| 2 | 233 | 0.69 | 0.85 | 28 | empty |
| 3 | 88 | 0.65 | 0.91 | 17 | empty |
| 4 | 207 | 0.52 | 0.77 | 47 | empty |
| 5 | 76 | 0.33 | 0.75 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–C · 640 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 498 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 473 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 1SZ9 · The RNA polymerase II CTD in mRNA processing: beta-turn recognition and beta-spiral model · the same entry in another collection · chain B against B, TM-score 1.00
- P39081 · AlphaFold monomer V2.0 prediction for protein PCF11 (P39081) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P39081
- Elsewhere: RCSB PDB 1SZ9 · PDBe 1SZ9 · UniProt P39081
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