MolNFT v1 · #22200 · protein
Crystal structure of the catalase-1 from neurospora crassa, native structure at 1.75A resolution.
1SY7 · Catalase 1: “Crystal structure of the catalase-1 from neurospora crassa, native structure at 1.75A resolution.”. X-ray diffraction, 2 ligands (HDD, HEM), 19 pockets (best druggability 0.81). MolNFT v1 #22200 on GenesisL1: 3D…
- PDB
- 1SY7
- Type
- protein
- Length
- 1,396 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Catalase 1
- EC
- 1.11.1.6
- UniProt
- Q9C168
- Ligands
- HDD, HEM
- Pockets
- 19 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Catalase 1 (EC 1.11.1.6) | protein | 698 | 31% helix, 17% strand | Q9C168 |
Ligands and binding sites
- HDD · Cis-heme D hydroxychlorin gamma-spirolactone · ligand · 2 copies · chains A, B
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
19 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 314 | 0.81 | 0.91 | 49 | HDD, HEM |
| 2 | 286 | 0.77 | 0.89 | 38 | HDD, HEM |
| 3 | 53 | 0.70 | 0.98 | 21 | empty |
| 4 | 50 | 0.70 | 0.98 | 22 | empty |
| 5 | 456 | 0.63 | 0.77 | 52 | empty |
Interfaces
1 interface between chains.
- A–B · 4544 Ų buried · 60 hydrogen bonds · protein-protein
Compared structures
- 1SY7 · Crystal structure of the catalase-1 from Neurospora crassa, native structure at 1.75A… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9C168 · AlphaFold monomer V2.0 prediction for catalase-1 (Q9C168) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9C168
- Elsewhere: RCSB PDB 1SY7 · PDBe 1SY7 · UniProt Q9C168
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.