MolNFT v1 · #22131 · protein
Crystal structure of prox from archeoglobus fulgidus in the ligand free form
1SW5 · Osmoprotection protein (prox): “Crystal structure of prox from archeoglobus fulgidus in the ligand free form”. X-ray diffraction, 2 ligands (MG, CL), 11 pockets (best druggability 0.79). MolNFT v1 #22131 on GenesisL1: 3D structure…
- PDB
- 1SW5
- Type
- protein
- Length
- 1,080 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Osmoprotection protein (prox)
- UniProt
- O29280
- Ligands
- MG, CL
- Pockets
- 11 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Osmoprotection protein (prox) | protein | 270 | 47% helix, 19% strand | O29280 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1163 | 0.79 | 0.81 | 99 | MG |
| 2 | 675 | 0.76 | 0.82 | 74 | empty |
| 3 | 337 | 0.64 | 0.80 | 36 | empty |
| 4 | 187 | 0.47 | 0.75 | 31 | empty |
| 5 | 166 | 0.45 | 0.75 | 30 | CL |
Interfaces
5 interfaces between chains.
- B–C · 423 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 417 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 397 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 359 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 285 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 1SW5 · Crystal structure of ProX from Archeoglobus fulgidus in the ligand free form · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O29280
- Elsewhere: RCSB PDB 1SW5 · PDBe 1SW5 · UniProt O29280
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