MolNFT v1 · #22130 · protein
Crystal structure of prox from archeoglobus fulgidus in complex with trimethyl ammonium
1SW4 · Osmoprotection protein (prox): “Crystal structure of prox from archeoglobus fulgidus in complex with trimethyl ammonium”. X-ray diffraction, 2 ligands (ZN, CL), 4 pockets (best druggability 0.56). MolNFT v1 #22130 on GenesisL1: 3D…
- PDB
- 1SW4
- Type
- protein
- Length
- 540 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Osmoprotection protein (prox)
- UniProt
- O29280
- Ligands
- ZN, CL
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Osmoprotection protein (prox) | protein | 270 | 44% helix, 19% strand | O29280 |
Ligands and binding sites
- ZN · Zinc ion · metal · 7 copies · chains A, B
- CL · Chloride ion · ion · 2 copies · chains A, B
- TMA · Tetramethylammonium ion · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 312 | 0.56 | 0.76 | 41 | empty |
| 2 | 255 | 0.55 | 0.77 | 24 | empty |
| 3 | 72 | 0.31 | 0.74 | 18 | empty |
| 4 | 62 | 0.29 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 502 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 1SW4 · Crystal structure of ProX from Archeoglobus fulgidus in complex with trimethyl ammonium · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O29280
- Elsewhere: RCSB PDB 1SW4 · PDBe 1SW4 · UniProt O29280
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.