MolNFT v1 · #2206 · protein
Differentiation and identification of the two catalytic metal binding sites in bovine lens leucine aminopeptidase by X-ray crystallography
1BPM: “Differentiation and identification of the two catalytic metal binding sites in bovine lens leucine…”. X-ray diffraction, 2 ligands (MG, ZN), 2 pockets (best druggability 0.49). MolNFT v1 #2206 on GenesisL1: 3D structure, binding…
- PDB
- 1BPM
- Type
- protein
- Length
- 481 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine aminopeptidase
- EC
- 3.4.11.1
- UniProt
- P00727
- Ligands
- MG, ZN
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucine aminopeptidase (EC 3.4.11.1) | protein | 481 | 38% helix, 20% strand | P00727 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 233 | 0.49 | 0.75 | 41 | empty |
| 2 | 126 | 0.41 | 0.75 | 22 | empty |
Compared structures
- 1BPM · Differentiation and identification of the two catalytic metal binding sites in bovine… · the same entry in another collection · chain A against A, TM-score 1.00
- P00727 · AlphaFold monomer V2.0 prediction for cytosol aminopeptidase (P00727) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00727
- Elsewhere: RCSB PDB 1BPM · PDBe 1BPM · UniProt P00727
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