MolNFT v1 · #22057 · protein
Crystal structure of a hypothetical protein at 2.2 a resolution
1STZ · Heat-inducible transcription repressor hrca homolog: “Crystal structure of a hypothetical protein at 2.2 a resolution”. X-ray diffraction, 9 pockets (best druggability 0.85). MolNFT v1 #22057 on GenesisL1: 3D structure, binding…
- PDB
- 1STZ
- Type
- protein
- Length
- 945 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat-inducible transcription repressor hrca homolog
- UniProt
- Q9WZV5
- Pockets
- 9 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat-inducible transcription repressor hrca homolog | protein | 323 | 49% helix, 20% strand | Q9WZV5 |
| B, C | Heat-inducible transcription repressor hrca homolog | protein | 311 | 47% helix, 21% strand | Q9WZV5 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1075 | 0.85 | 0.85 | 99 | empty |
| 2 | 280 | 0.64 | 0.81 | 39 | empty |
| 3 | 85 | 0.51 | 0.83 | 20 | empty |
| 4 | 236 | 0.48 | 0.74 | 30 | empty |
| 5 | 57 | 0.48 | 0.85 | 23 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1718 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 662 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 654 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 1STZ · Crystal structure of a hypothetical protein at 2.2 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
- Q9WZV5 · AlphaFold monomer V2.0 prediction for heat-inducible transcription repressor hrca (Q9WZV5) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WZV5
- Elsewhere: RCSB PDB 1STZ · PDBe 1STZ · UniProt Q9WZV5
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