MolNFT v1 · #21897 · protein
NMR structure of aquifex aeolicus 5,10-methenyltetrahydrofolate synthetase: northeast structural genomics consortium target QR46
1SOU: “NMR structure of aquifex aeolicus 5,10-methenyltetrahydrofolate synthetase: northeast structural genomics…”. Solution nmr, 2 pockets (best druggability 0.67). MolNFT v1 #21897 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1SOU
- Type
- protein
- Length
- 194 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5,10-methenyltetrahydrofolate synthetase
- EC
- 6.3.3.2
- UniProt
- O67621
- Pockets
- 2 · best druggability 0.67
Structure
solution nmr · 1 distinct chain · 29% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5,10-methenyltetrahydrofolate synthetase (EC 6.3.3.2) | protein | 194 | 29% helix, 22% strand | O67621 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 330 | 0.67 | 0.81 | 37 | empty |
| 2 | 57 | 0.51 | 0.86 | 19 | empty |
Compared structures
- 1SOU · NMR structure of Aquifex aeolicus 5,10-methenyltetrahydrofolate synthetase: Northeast… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O67621
- Elsewhere: RCSB PDB 1SOU · PDBe 1SOU · UniProt O67621
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