MolNFT v1 · #21842 · protein

Crystal structure of sea bream transthyretin at 1.90A resolution

1SN2: “Crystal structure of sea bream transthyretin at 1.90A resolution”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.66). MolNFT v1 #21842 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1SN2
Type: protein
Length: 463 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transthyretin
UniProt: Q9PTT3
Ligands: SO4
Pockets: 3 · best druggability 0.66

Structure

x-ray diffraction · 4 distinct chains · 8% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transthyretin	protein	118	6% helix, 47% strand	Q9PTT3
B	Transthyretin	protein	116	9% helix, 51% strand	Q9PTT3
C	Transthyretin	protein	115	7% helix, 50% strand	Q9PTT3
D	Transthyretin	protein	114	10% helix, 48% strand	Q9PTT3

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	303	0.66	0.81	39	empty
2	325	0.65	0.81	39	empty
3	57	0.28	0.74	18	empty

Interfaces

6 interfaces between chains.

A–B · 934 Å² buried · 22 hydrogen bonds · protein-protein
C–D · 930 Å² buried · 23 hydrogen bonds · protein-protein
A–C · 598 Å² buried · 7 hydrogen bonds · protein-protein
B–D · 386 Å² buried · 2 hydrogen bonds · protein-protein
A–D · 355 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

1SN2 · Crystal Structure of Sea Bream Transthyretin at 1.90A Resolution · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9PTT3
Elsewhere: RCSB PDB 1SN2 · PDBe 1SN2 · UniProt Q9PTT3

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.