MolNFT v1 · #21825 · protein

Metallo beta lactamase L1 from stenotrophomonas maltophilia

1SML · Protein (penicillinase): “Metallo beta lactamase L1 from stenotrophomonas maltophilia”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.39). MolNFT v1 #21825 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1SML
Type: protein
Length: 266 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (penicillinase)
EC: 3.5.2.6
UniProt: P52700
Ligands: ZN
Pockets: 2 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (penicillinase) (EC 3.5.2.6)	protein	266	31% helix, 24% strand	P52700

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	97	0.39	0.76	26	ZN
2	70	0.31	0.74	15	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1SML · Metallo beta lactamase L1 from stenotrophomonas maltophilia · the same entry in another collection · chain A against A, TM-score 1.00
P52700 · AlphaFold monomer V2.0 prediction for metallo-beta-lactamase L1 type 3 (P52700) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52700
Elsewhere: RCSB PDB 1SML · PDBe 1SML · UniProt P52700

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