MolNFT v1 · #21723 · protein
Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization
1SJI · Calsequestrin, cardiac muscle isoform: “Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for…”. X-ray diffraction, 13 pockets (best druggability 0.82). MolNFT v1 #21723 on…
- PDB
- 1SJI
- Type
- protein
- Length
- 700 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calsequestrin, cardiac muscle isoform
- UniProt
- P12637
- Pockets
- 13 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Calsequestrin, cardiac muscle isoform | protein | 350 | 38% helix, 20% strand | P12637 |
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 814 | 0.82 | 0.85 | 95 | empty |
| 2 | 199 | 0.67 | 0.85 | 26 | empty |
| 3 | 287 | 0.64 | 0.81 | 27 | empty |
| 4 | 135 | 0.50 | 0.79 | 20 | empty |
| 5 | 79 | 0.50 | 0.83 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1878 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 1SJI · Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a… · the same entry in another collection · chain A against A, TM-score 1.00
- P12637 · AlphaFold monomer V2.0 prediction for calsequestrin-2 (P12637) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12637
- Elsewhere: RCSB PDB 1SJI · PDBe 1SJI · UniProt P12637
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