MolNFT v1 · #21637 · protein
Structure of tRNA PSI55 pseudouridine synthase (trub)
1SGV · TRNA pseudouridine synthase B: “Structure of tRNA PSI55 pseudouridine synthase (trub)”. X-ray diffraction, 4 pockets (best druggability 0.66). MolNFT v1 #21637 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1SGV
- Type
- protein
- Length
- 528 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA pseudouridine synthase B
- EC
- 4.2.1.70
- UniProt
- P62190
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA pseudouridine synthase B (EC 4.2.1.70) | protein | 262 | 26% helix, 38% strand | P62190 |
| B | TRNA pseudouridine synthase B (EC 4.2.1.70) | protein | 266 | 26% helix, 36% strand | P62190 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 386 | 0.66 | 0.80 | 54 | empty |
| 2 | 157 | 0.49 | 0.78 | 29 | empty |
| 3 | 60 | 0.36 | 0.79 | 23 | empty |
| 4 | 55 | 0.31 | 0.76 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1122 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 1SGV · Structure of tRNA PSI55 pseudouridine synthase (trub) · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62190
- Elsewhere: RCSB PDB 1SGV · PDBe 1SGV · UniProt P62190
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