MolNFT v1 · #21498 · protein

Crystal structure of the cell cycle regulatory protein SUC1 reveals a novel beta-hinge conformational switch

1SCE: “Crystal structure of the cell cycle regulatory protein SUC1 reveals a novel beta-hinge conformational switch”. X-ray diffraction, 1 ligand (CL), 4 pockets (best druggability 0.64). MolNFT v1 #21498 on GenesisL1: 3D structure…

PDB: 1SCE
Type: protein
Length: 408 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SUC1
UniProt: P08463
Ligands: CL
Pockets: 4 · best druggability 0.64

Structure

x-ray diffraction · 3 distinct chains · 25% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	SUC1	protein	97	27% helix, 24% strand	P08463
C	SUC1	protein	111	23% helix, 21% strand	P08463
D	SUC1	protein	103	26% helix, 19% strand	P08463

Ligands and binding sites

CL · Chloride ion · ion · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	201	0.64	0.83	36	empty
2	66	0.54	0.87	18	empty
3	195	0.49	0.76	30	CL
4	138	0.38	0.73	20	empty

Interfaces

5 interfaces between chains.

A–C · 2283 Å² buried · 39 hydrogen bonds · protein-protein
B–D · 2190 Å² buried · 34 hydrogen bonds · protein-protein
A–B · 694 Å² buried · 5 hydrogen bonds · protein-protein
A–D · 97 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 84 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1SCE · Crystal structure of the cell cycle regulatory protein SUC1 reveals a novel beta-hinge… · the same entry in another collection · chain D against D, TM-score 1.00
P08463 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinases regulatory subunit (P08463) · a predicted model of the same protein · chain B against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08463
Elsewhere: RCSB PDB 1SCE · PDBe 1SCE · UniProt P08463

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.