MolNFT v1 · #21490 · protein
Sigma-28(FLIA)/FLGM complex
1SC5 · RNA polymerase sigma factor flia: “Sigma-28(FLIA)/FLGM complex”. X-ray diffraction, 3 pockets (best druggability 0.42). MolNFT v1 #21490 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1SC5
- Type
- protein
- Length
- 300 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase sigma factor flia; Anti-sigma factor flgm
- UniProt
- O67268, O66683
- Pockets
- 3 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA polymerase sigma factor flia | protein | 228 | 75% helix, 0% strand | O67268 |
| B | Anti-sigma factor flgm | protein | 72 | 71% helix, 0% strand | O66683 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 162 | 0.42 | 0.74 | 29 | empty |
| 2 | 134 | 0.40 | 0.74 | 24 | empty |
| 3 | 53 | 0.32 | 0.77 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1695 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 1SC5 · Sigma-28(FliA)/FlgM complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O67268
- Every structure of UniProt O66683
- Elsewhere: RCSB PDB 1SC5 · PDBe 1SC5 · UniProt O67268 · UniProt O66683
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