MolNFT v1 · #21345 · protein
Complex between protein SER/THR phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1)
1S70 · SERINE/THREONINE protein phosphatase PP1-beta (or delta)…: “Complex between protein SER/THR phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1)”. X-ray diffraction, 1 ligand (MN), 6 pockets (best…
- PDB
- 1S70
- Type
- protein
- Length
- 600 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE protein phosphatase PP1-beta (or delta) catalytic subunit; 130 kda…
- EC
- 3.1.3.16, 3.1.3.53
- UniProt
- P62140, Q90624
- Ligands
- MN
- Pockets
- 6 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE protein phosphatase PP1-beta (or delta) catalytic subunit (EC 3.1.3.16) | protein | 309 | 31% helix, 17% strand | P62140 |
| B | 130 kda myosin-binding subunit of smooth muscle myosin phophatase (M130) (EC 3.1.3.53) | protein | 291 | 53% helix, 1% strand | Q90624 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 2 copies · chains A
- PGE · Triethylene glycol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 307 | 0.61 | 0.79 | 35 | PGE |
| 2 | 409 | 0.60 | 0.76 | 56 | empty |
| 3 | 191 | 0.51 | 0.77 | 24 | empty |
| 4 | 168 | 0.47 | 0.76 | 21 | empty |
| 5 | 166 | 0.46 | 0.76 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 2616 Ų buried · 37 hydrogen bonds · protein-protein
Compared structures
- 1S70 · Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase… · the same entry in another collection · chain A against A, TM-score 1.00
- P62140 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase PP1-beta… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62140
- Every structure of UniProt Q90624
- Elsewhere: RCSB PDB 1S70 · PDBe 1S70 · UniProt P62140 · UniProt Q90624
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