MolNFT v1 · #21311 · protein

Crystal structure analysis of a mutant of dihydrodipicolinate synthase--residue TYR133 to PHE133

1S5W: “Crystal structure analysis of a mutant of dihydrodipicolinate synthase--residue TYR133 to PHE133”. X-ray diffraction, 4 pockets (best druggability 0.58). MolNFT v1 #21311 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1S5W
Type: protein
Length: 584 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dihydrodipicolinate synthase
EC: 4.2.1.52
UniProt: P0A6L2
Pockets: 4 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Dihydrodipicolinate synthase (EC 4.2.1.52)	protein	292	46% helix, 13% strand	P0A6L2

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	192	0.58	0.81	36	empty
2	200	0.56	0.79	31	empty
3	90	0.45	0.80	20	empty
4	81	0.44	0.80	20	empty

Compared structures

1S5W · Crystal Structure Analysis of a mutant of DIHYDRODIPICOLINATE SYNTHASE--residue Tyr133 to… · the same entry in another collection · chain A against A, TM-score 1.00
P0A6L2 · AlphaFold monomer V2.0 prediction for 4-hydroxy- tetrahydrodipicolinate synthase (P0A6L2) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A6L2
Elsewhere: RCSB PDB 1S5W · PDBe 1S5W · UniProt P0A6L2

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