MolNFT v1 · #21306 · protein

Solution structure of HBP1 sid-MSIN3A PAH2 complex

1S5R · High mobility group box transcription factor 1: “Solution structure of HBP1 sid-MSIN3A PAH2 complex”. Solution nmr, 1 pocket (best druggability 0.29). MolNFT v1 #21306 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1S5R
Type: protein
Length: 112 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: High mobility group box transcription factor 1; SIN3A protein
UniProt: Q8BUS3, Q60520
Pockets: 1 · best druggability 0.29

Structure

solution nmr · 2 distinct chains · 62% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	High mobility group box transcription factor 1	protein	23	43% helix, 0% strand	Q8BUS3
B	SIN3A protein	protein	89	66% helix, 0% strand	Q60520

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	58	0.29	0.74	12	empty

Interfaces

1 interface between chains.

A–B · 1007 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

1S5R · Solution Structure of HBP1 SID-mSin3A PAH2 Complex · the same entry in another collection · chain A against A, TM-score 1.00
Q60520 · AlphaFold monomer V2.0 prediction for paired amphipathic helix protein SIN3A (Q60520) · a predicted model of the same protein · chain B against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8BUS3
Every structure of UniProt Q60520
Elsewhere: RCSB PDB 1S5R · PDBe 1S5R · UniProt Q8BUS3 · UniProt Q60520

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