MolNFT v1 · #21305 · protein

Solution structure of MAD1 sid-MSIN3A PAH2 complex

1S5Q · Mad protein: “Solution structure of MAD1 sid-MSIN3A PAH2 complex”. Solution nmr, 1 pocket (best druggability 0.31). MolNFT v1 #21305 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1S5Q
Type: protein
Length: 105 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mad protein; SIN3A protein
UniProt: Q05195, Q60520
Pockets: 1 · best druggability 0.31

Structure

solution nmr · 2 distinct chains · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mad protein	protein	16	69% helix, 0% strand	Q05195
B	SIN3A protein	protein	89	69% helix, 0% strand	Q60520

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.31	0.76	13	empty

Interfaces

1 interface between chains.

A–B · 855 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

1S5Q · Solution Structure of Mad1 SID-mSin3A PAH2 Complex · the same entry in another collection · chain A against A, TM-score 1.00
Q60520 · AlphaFold monomer V2.0 prediction for paired amphipathic helix protein SIN3A (Q60520) · a predicted model of the same protein · chain B against A, TM-score 0.85
Q05195 · AlphaFold monomer V2.0 prediction for max dimerization protein 1 (Q05195) · a predicted model of the same protein · chain A against A, TM-score 0.66

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q05195
Every structure of UniProt Q60520
Elsewhere: RCSB PDB 1S5Q · PDBe 1S5Q · UniProt Q05195 · UniProt Q60520

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