MolNFT v1 · #21278 · protein
HP1 chromo shadow domain in complex with pxvxl motif of caf-1
1S4Z · Chromobox protein homolog 1: “HP1 chromo shadow domain in complex with pxvxl motif of caf-1”. Solution nmr, 2 pockets (best druggability 0.43). MolNFT v1 #21278 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1S4Z
- Type
- protein
- Length
- 180 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromobox protein homolog 1; Chromatin assembly factor 1 subunit a
- UniProt
- P23197, Q9QWF0
- Pockets
- 2 · best druggability 0.43
Structure
solution nmr · 2 distinct chains · 16% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Chromobox protein homolog 1 | protein | 75 | 23% helix, 17% strand | P23197 |
| C | Chromatin assembly factor 1 subunit a | protein | 30 | 0% helix, 10% strand | Q9QWF0 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 103 | 0.43 | 0.78 | 23 | empty |
| 2 | 77 | 0.39 | 0.78 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–C · 725 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 700 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 686 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 1S4Z · HP1 chromo shadow domain in complex with PXVXL motif of CAF-1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9QWF0 · AlphaFold monomer V2.0 prediction for chromatin assembly factor 1 subunit a (Q9QWF0) · a predicted model of the same protein · chain C against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23197
- Every structure of UniProt Q9QWF0
- Elsewhere: RCSB PDB 1S4Z · PDBe 1S4Z · UniProt P23197 · UniProt Q9QWF0
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