MolNFT v1 · #21269 · protein
Crystal structure of guanylate kinase from mycobacterium tuberculosis (RV1389)
1S4Q: “Crystal structure of guanylate kinase from mycobacterium tuberculosis (RV1389)”. X-ray diffraction, 1 ligand (CL), 1 pocket (best druggability 0.38). MolNFT v1 #21269 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1S4Q
- Type
- protein
- Length
- 183 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanylate kinase
- EC
- 2.7.4.8
- UniProt
- P0A5I4
- Ligands
- CL
- Pockets
- 1 · best druggability 0.38
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanylate kinase (EC 2.7.4.8) | protein | 183 | 45% helix, 22% strand | P0A5I4 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 121 | 0.38 | 0.74 | 20 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1S4Q · Crystal Structure of Guanylate Kinase from Mycobacterium tuberculosis (Rv1389) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A5I4
- Elsewhere: RCSB PDB 1S4Q · PDBe 1S4Q · UniProt P0A5I4
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