MolNFT v1 · #21247 · protein + DNA
Solution structure of the CDC13 DNA-binding domain complexed with a single-stranded telomeric DNA 11-mer
1S40 · 5'-D(*GP*TP*GP*TP*GP*GP*GP*TP*GP*TP*G)-3': “Solution structure of the CDC13 DNA-binding domain complexed with a single-stranded telomeric DNA 11-mer”. Solution nmr, 3 pockets (best druggability 0.70). MolNFT v1 #21247 on GenesisL1…
- PDB
- 1S40
- Type
- protein + DNA
- Length
- 198 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-D(*GP*TP*GP*TP*GP*GP*GP*TP*GP*TP*G)-3'; Cell division control protein 13
- UniProt
- P32797
- Pockets
- 3 · best druggability 0.70
Structure
solution nmr · 2 distinct chains · 27% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | 5'-D(*GP*TP*GP*TP*GP*GP*GP*TP*GP*TP*G)-3' | dna | 11 | — | — |
| A | Cell division control protein 13 | protein | 187 | 27% helix, 20% strand | P32797 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.70 | 0.87 | 28 | empty |
| 2 | 60 | 0.51 | 0.86 | 11 | empty |
| 3 | 62 | 0.35 | 0.78 | 16 | empty |
Interfaces
1 interface between chains.
- B–A · 1388 Ų buried · 30 hydrogen bonds · protein-nucleic
Compared structures
- 1S40 · Solution structure of the CDC13 DNA-binding domain complexed with a single-stranded… · the same entry in another collection · chain B against B, TM-score 1.00
- P32797 · AlphaFold monomer V2.0 prediction for cell division control protein 13 (P32797) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32797
- Elsewhere: RCSB PDB 1S40 · PDBe 1S40 · UniProt P32797
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